Basic information Safety Related Supplier
SAXITOXIN Structure

SAXITOXIN

Chemical Properties

Boiling point 440.62°C (rough estimate)
Density  1.3010 (rough estimate)
refractive index  1.6400 (estimate)
storage temp.  −20°C
pka 13.32±0.50(Predicted)
EPA Substance Registry System Saxitoxin (35523-89-8)

Safety Information

Hazard Codes  T+
Risk Statements  26/27/28
Safety Statements  36/37/39-45
RIDADR  UN 3462 6.1/PG 1
WGK Germany  3
Toxicity During seasons when dinoflagellates “bloom,” filter-feeding shellfish become contaminated with accumulated toxin and are toxic when eaten. STX blocks nerve membrane sodium channels in nanomolar concentrations when applied externally. STX competes with tetrodotoxin (TTX) for binding to sodium channels. The mechanism of action on nerves is the same as that of TTX, although recovery from STX block occurs slightly faster than that after TTX block. The i.p. LD50 in mice is 10 μg/kg. Symptoms in humans within 30 min of ingestion include tingling and burning in face, lips, tongue, and eventually the whole body, parathesia followed by numbness, ataxia, general motor incoordination, confusion, and headache. Death due to respiratory paralysis occurs within 12 h. Treatment is restricted to symptoms. There is no antidote, and emesis is advisable. Artificial respiration is given if neces_x0002_sary. Prostigmine methylsulfate (1 mL of 1:2000 solution, i.v.) is helpful.

MSDS

Usage And Synthesis