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2,3-Dichlorobenzoic acid

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2,3-Dichlorobenzoic acid Basic information
2,3-Dichlorobenzoic acid Chemical Properties
  • Melting point:168-170 °C (lit.)
  • Boiling point:273.68°C (rough estimate)
  • Density 1.4410 (rough estimate)
  • refractive index 1.4590 (estimate)
  • storage temp. Sealed in dry,Room Temperature
  • form neat
  • pka2.53±0.25(Predicted)
  • Water Solubility slightly soluble
  • BRN 1946217
  • InChIKeyQAOJBHRZQQDFHA-UHFFFAOYSA-N
  • CAS DataBase Reference50-45-3(CAS DataBase Reference)
  • EPA Substance Registry System2,3-Dichlorobenzoic acid (50-45-3)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-37/39-36-24/25
  • WGK Germany 2
  • RTECS DG6475000
  • HazardClass IRRITANT
  • HS Code 29163990
MSDS
2,3-Dichlorobenzoic acid Usage And Synthesis
  • Chemical Propertieswhite to light yellow crystal powder
  • Uses2,3-Dichlorobenzoic acid is the key intermediate for antiepileptic drug Lamotrigine (L173250) and other pharmaceuticals for the treatment of central nervous system (CNS) disorders and disease.
  • Purification MethodsAromatic acid impurities (to <0.05%) can be removed via the (±)--methylbenzylamine salt as described for 2,4-dichlorobenzoic acid [Ley & Yates Organic Process Research & Development 12 120 2008.] Crystallise the acid from H2O, aqueous EtOH, or 30% aqueous AcOH and several times from *C6H6, then dry it in vacuo at 40o overnight. The methyl ester has m 35-39o . [Hope & Riley J Chem Soc 123 2478 1923, Lock Monatsh Chem 90 687 1959, Shorter & Mather J Chem Soc 4744 1961, Beilstein 9 II 228, 9 IV 998.]
2,3-Dichlorobenzoic acid Preparation Products And Raw materials
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