Gly-Pro-Glu (GPE) is a neuroactive peptide and prevents the binding of glutamate to N-methyl-D-aspartate (NMDA) receptor. It positively regulates the potassium-mediated release of acetylcholine from r at cortical slices. Thus, it is involved in the control of brain function. In vitro studies show th at this peptide confers neuroprotection to CA1-2 hippocampal neurons against excitotoxic insult.', 'Gly-Pro-Glu is a neuroprotective compound and the N-terminal tripeptide of IGF-1. Gly-Pro-Glu is neuroprotective after central administration in animal models of neurodegenerative processes, such as Huntington′s, Parkinson′s, Alzheimer′s diseases, and varies acute brain injury animal models. The neuroprotective activity is not related to its affinity to glutamate receptor. Findings indicate th at GPE mimics insulin-like growth factor I effects on the somatostatin system through a mechanism independent of β-amyloid clearance th at involves modulation of calcium and glycogen synthase kinase 3β signaling.
