ChemicalBook Product Catalog Chemical Reagents Organic reagents Phosphine ligand (R)-1-[(S)-2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]PHOSPHINO]FERROCENYL]-ETHYLDI-TERT-BUTYLPHOSPHINE

(R)-1-[(S)-2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]PHOSPHINO]FERROCENYL]-ETHYLDI-TERT-BUTYLPHOSPHINE

Product Name(R)-1-[(S)-2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]PHOSPHINO]FERROCENYL]-ETHYLDI-TERT-BUTYLPHOSPHINE
CAS246231-79-8
MFC34H32F6FeP2
MW672.41
EINECS
MOL File246231-79-8.mol

Chemical Properties

alpha	-352° ±10° (c 0.5, CHCl3)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Powder
color	orange

Safety Information

Risk Statements	36/37/38
Safety Statements	24/25
WGK Germany	3
HS Code	29319090

MSDS

Provider	Language
ACROS	English

Usage And Synthesis

Reaction

Ferrocenylphosphine ligands of the type cpFecp(PR2)(*CH(CH3)PR'2) are a class of asymmetric ligands developed at Solvias in Basel, Switzerland. Ligands of this type are currently used industrially in the stereoselective synthesis of commercial products. A unique feature of these bidentate ligands is the presence of a fixed phosphine moiety and a stereogenic, functionalized side chain, which can be easily modified to accommodate electronic and steric requirements. Based on a versatile synthetic procedure starting with optically active ferrocenes of the type cpFecp(PR2)(*CH(CH3)X) [X = OAc or NR2], a variety of donor atoms can be introduced into the side chain. These ferrocene based phosphine ligands have wide application in the stereoselective hydrogenation of substituted acetamidoacrylates, enol acetates, β-ketoesters and simple alkenes.
Useful as a ligand in Pd-catalyzed C-N bond-forming reactions.
Pd-catalyzed enantioselective alkylative desymmetrization of meso-succinic anhydrides.
Asymmetric hydrogenation of ketones and phosphinylketimines.
Michael addition of Grignard reagents to α,α-unsaturated esters and thioesters.
Boration of α,α-unsaturated esters and nitriles.
Reaction of aryl halides with ammonia.
Cu-catalyzed reduction of activated C=C bonds with PMHS.
Regio- and enantioselective hydroboration of vinyl arenes.
Rh-catalyzed asymmetric ring-opening reactions of oxabicyclic alkenes.
1,2-Migrations in Pd-catalyzed Negishi couplings with JosiPhos ligands.
Catalyst for the homodimerization of ketoketenes.
Ligand for the Rh catalyzed synthesis of lactones.
Ligand for the Cu-catalyzed synthesis of syn and anti γ-amino alcohols.

Chemical Properties

Orange powder

General Description

sold in collaboration with Solvias AG

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