Hydroxyanilide fungicide.
ChEBI: Fenhexamid is an aromatic amide resulting from the formal condensation of the carboxy group of 1-methylcyclohexanecarboxylic acid with the amino group of 4-amino-2,3-dichlorophenol. It has a role as an EC 1.14.13.72 (methylsterol monooxygenase) inhibitor, a sterol biosynthesis inhibitor and an antifungal agrochemical. It is a dichlorobenzene, a monocarboxylic acid amide, a member of phenols, an aromatic amide and an anilide fungicide.
Low toxicity by ingestion, inhalation, and
skin contact.
Fungicide: Fungicide; for control of Botrytis cinerea and related
diseases on Rubus, Ribes, bushberries, caneberries,
grapes, pistachios, strawberries, ornamentals and other
crops. Control of Monilinia diseases of almonds and stone
fruit. On grapes and grapevines for suppression of powdery
mildew and to control bunch rot[83].
Low toxicity, high safety: Acute oral LD₅₀ (rats): males > 5000 mg/kg; acute dermal LD₅₀ (rats, 24 hours): > 5000 mg/kg; acute inhalation LC₅₀ (4 hours, rats): > 5057 mg/kg air. Non-irritating to rabbit skin and eyes; no teratogenic or carcinogenic effects.
Fenhexamid is a systemic, protective amide fungicide developed by Bayer in 1989. Its mode of action involves inhibiting sterol biosynthesis—specifically by targeting 3-ketoreductase—to prevent C4 demethylation, which halts fungal conidiophore and hyphal growth. This unique mechanism provides excellent activity against resistant strains. Furthermore, it can be formulated with various active ingredients, such as tebuconazole, fenarimol, carbendazim, flupyrazole, pyraclostrobin, and imazalil.
[1] Xu, Xinxin et al. “A strategy for the free-formulation application of hydrophobic pesticides: achieving efficient and multifunctional utilization to promote green and sustainable agriculture.” Pest Management Science 81 7 (2025): 4016–4026.
https://doi.org/10.1002/ps.8776
