Example 47: Synthesis of 1,3-dimethyl-1H-pyrazole-5-carboxamide; Ethyl 1,3-dimethyl-1H-pyrazole-5-carboxylate (9.5 g, 56.5 mmol, 1.0 eq.) was dissolved in an aqueous solution of ammonium hydroxide and the reaction was stirred for 16.5 hours at room temperature. Upon completion of the reaction, the organic layer was extracted with a 10% isopropanol/chloroform solvent mixture, followed by washing the organic layer with saturated aqueous sodium chloride solution and drying with anhydrous magnesium sulfate. Finally, the solvent was removed by concentration under reduced pressure to give a white solid product (6.0 g, 77% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.78 (s, 1H), 7.38 (s, 1H), 6.59 (s, 1H), 3.94 (s, 3H), 2.12 (s, 3H). lC-MS (ESI+) analysis showed that m/z 140 corresponded to the [M+H]+ ion of C6H9N3O.
