去甲槟榔次碱
去甲槟榔次碱 性质
| 熔点 | 316 °C (decomp) |
|---|---|
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 在水中可溶 |
| 形态 | 固体 |
| 颜色 | 白色 |
| 水溶解性 | H2O: soluble ethanol: slightly soluble |
| InChI | InChI=1S/C6H9NO2.ClH/c8-6(9)5-2-1-3-7-4-5;/h2,7H,1,3-4H2,(H,8,9);1H |
| InChIKey | FGNUNVVTHHKDAM-UHFFFAOYSA-N |
| SMILES | C1(C(=O)O)CNCCC=1.[H]Cl |
去甲槟榔次碱 用途与合成方法
IC50: 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), 1870 μM (human BGT-3)
Guvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity for cloned GABA transporters with IC 50 s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC 50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC 50 s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively.
安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 26-36 |
| WGK Germany | 3 |
| 危险等级 | IRRITANT |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 眼部刺激 类别2 经皮刺激 类别2 特异性靶器官毒性-一次接触，类别3 |
去甲槟榔次碱 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-100809 | 去甲槟榔次碱 | 6027-91-4 | 1 mg | 156 |
| 2026-09-15 | HY-100809 | 去甲槟榔次碱 | 6027-91-4 | 5 mg | 346 |
