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THAPSIGARGIN

Basic information Safety Related Supplier
THAPSIGARGIN Basic information
THAPSIGARGIN Chemical Properties
  • Boiling point:597.77°C (rough estimate)
  • Density 1.1521 (rough estimate)
  • refractive index 1.6390 (estimate)
  • RTECS RH0325700
  • storage temp. −20°C
  • solubility DMSO: soluble
  • form liquid or film
  • pka10.57±0.70(Predicted)
  • color Colorless
  • Sensitive Light Sensitive
  • CAS DataBase Reference67526-95-8(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xn,T
  • Risk Statements 36/37/38-42
  • Safety Statements 26-36/37/39
  • RIDADR UN 2811 6.1/PG 2
  • WGK Germany 3
  • HS Code 29181990
MSDS
THAPSIGARGIN Usage And Synthesis
  • Chemical PropertiesTHAPSIGARGIN is colourless film
  • UsesTHAPSIGARGIN is a widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. It induces apoptosis by disrupting intracellular free Ca2+ levels.
  • UsesReagent for defining and manipulating intracellular calcium pools.
  • DefinitionTHAPSIGARGIN is an organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargi inhibits Ca2+-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
  • Biological ActivityPotent inhibitor of sarco-endoplasmic reticulum Ca 2+ -ATPases.
THAPSIGARGIN(67526-95-8)Related Product Information
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