2,5-DIBROMOTHIAZOLE

3034-22-8

4175-78-4

2-Amino-5-bromothiazole (5.5 g, 30.72 mmol) was used as starting material and dissolved in acetonitrile (50 mL). Copper (II) bromide (3.43 g, 15.36 mmol) and isoamyl nitrite (4.9 mL, 36.87 mmol) were added sequentially. The reaction mixture was heated at 60 °C for 4 h with stirring. After completion of the reaction, the volatile solvent was removed by rotary evaporator. The residue was diluted with distilled water (50 mL) and subsequently extracted with ethyl acetate (25 mL x 2). The organic phases were combined, washed with saturated saline (50 mL) and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (60-120 mesh, eluent 10% ethyl acetate in hexane solution) to afford the target compound 2,5-dibromothiazole (5.05 g, yield 68%) as a yellow liquid. m/z 243.6 [M+2] by LCMS.