Basic information Safety Related Supplier

NIGERICIN SODIUM SALT

Basic information Safety Related Supplier
NIGERICIN SODIUM SALT Basic information
NIGERICIN SODIUM SALT Chemical Properties
  • Melting point:183.5-185°
  • alpha D24 +36.2° (c = 0.842 in CHCl3)
  • Boiling point:779.9±60.0 °C(Predicted)
  • Density 1.19±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility chloroform: 10 mg/mL, clear, colorless
  • pka4.39±0.10(Predicted)
Safety Information
  • Hazard Codes T,Xi
  • Risk Statements 25-36/37/38
  • Safety Statements 26-36/37/39-45-36
  • RIDADR UN 3462 6.1/PG 3
  • WGK Germany 3
  • RTECS QT6840000
  • 10
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29419090
  • ToxicityLD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned)
MSDS
NIGERICIN SODIUM SALT Usage And Synthesis
  • UsesNigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.
  • DefinitionChEBI: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.
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