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Desoxycorticosterone

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Desoxycorticosterone Basic information
Desoxycorticosterone Chemical Properties
  • Melting point:138-144 °C
  • alpha 184 º (c=1, C2H5OH)
  • Boiling point:407.89°C (rough estimate)
  • Density 1.0998 (rough estimate)
  • refractive index 1.5192 (estimate)
  • Flash point:9℃
  • storage temp. ?20°C
  • pka12.98±0.10(Predicted)
  • Water Solubility slightly soluble
  • Merck 13,2917
  • BRN 2062123
  • CAS DataBase Reference64-85-7(CAS DataBase Reference)
  • NIST Chemistry ReferenceDeoxycorticosterone(64-85-7)
  • EPA Substance Registry SystemDeoxycorticosterone (64-85-7)
Safety Information
MSDS
Desoxycorticosterone Usage And Synthesis
  • Chemical Propertieswhite to creamy-white crystalline powder
  • UsesA mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700).
  • UsesAntiinflammatory;Corticoide
  • DefinitionChEBI: A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group.
  • HazardToxic.
  • Mechanism of actionDesoxycorticosterone causes an increase in reabsorption of sodium ions and excretion of potassium ions from the renal tubules, which leads to increased tissue hydrophilicity. This facilitates an elevated volume of plasma and increased arterial pressure. Muscle tonicity and work capability are increased. It is used for an insufficiency of function of the adrenal cortex, myasthenia, asthenia, adynamia, and overall muscle weakness.
  • Chemical SynthesisDesoxycorticosterone, 21-hydroxypregn-4-en-3,20-dione acetate (27.2.6), is synthesized in a number of ways, the easiest of which being iodination of progesterone at C21 in the methyl group, and subsequent reaction of the resulting iodo-derivative 27.2.5 with potassium acetate, which leads to formation of the desired desoxycorticosterone in the form of the acetate (27.2.6) .

  • Purification MethodsCrystallise 11-deoxycorticosterone from diethyl ether. [Schindler et al. Helv Chim Acta 24 360 1941, Steiger & Reichstein Helv Chim Acta 20 1164 1937.]
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