N,N'-(2,2'-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonaMide

CMPDA is a positive allosteric modulator of the ionotropic glutamate receptor GluA2. It increases glutamate-induced calcium influx into HEK293 cells expressing human GluA2i or GluA2o receptors (EC₅₀s = 45.4 and 63.4 nM, respectively). CMPDA (10 μM) inhibits desensitization of rat GluA2o and GluA2i receptors, as well as slows the rate of deactivation of GluA2o, but not GluA2i, receptors, in HEK293 cells.

CMPDA (cas# 380607-77-2) is a useful research chemical.CMPDA is a new positive allosteric modulator of AMPA receptor.