基本属性 用途生物活性靶点体外研究体内研究 用途与合成方法 W-54011 价格(试剂级) 供应商 相关产品
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W-54011

W-54011

中文名称:W-54011
英文名称:N-[[4-(DIMETHYLAMINO)PHENYL]METHYL]-1,2,3,4-TETRAHYDRO-7-METHOXY-N-[4-(1-METHYLETHYL)PHENYL]-1-NAPHTHALENECARBOXAMIDE HYDROCHLORIDE
CAS号:405098-33-1
分子式:C30H37ClN2O2
分子量:493.08
EINECS号:
Mol文件:405098-33-1.mol
W-54011 结构式

W-54011 性质

储存条件 Store at -20°C
溶解度 DMF:30mg/mL;二甲基亚砜:30mg/mL;乙醇:3mg/mL
形态 白色粉末状固体。
稳定性 吸湿性

W-54011 用途与合成方法

W-54011是一种有效的口服非肽C5a受体拮抗剂。 W-54011 是一种有效的,具有口服活性的非肽 C5a 受体拮抗剂。W-54011 抑制 125I 标记的 C5a 与人嗜中性白细胞的结合,Ki 值为 2.2 nM。W-54011 还抑制 C5a 诱导的人嗜中性粒细胞的细胞内 Ca2+ 动员,趋化性和 ROS 的生成,IC50 值分别为 3.1 nM、2.7 nM 和1.6 nM。

Ki: 2.2 nM (C5a)sup>[1]
IC50: 3.1 nM (Ca 2+ mobilization,), 2.7 nM (Chemotaxis), and 1.6 nM (ROS)

In C5a-induced intracellular Ca 2+ mobilization assay with human neutrophils, W-54011 does not show agonistic activity at up to 10 μM and shifts rightward the concentration-response curves to C5a without depressing the maximal responses, indicating that W-54011 is a full antagonist. At concentrations up to 10 μM, W-54011 does not affect Ca2+ mobilization stimulated with sub-maximally effective concentrations of fMLP (1 nM), plateletactivating factor (0.3 nM), and IL-8 (0.1 nM). This result demonstrates that W-54011 is highly specific for C5a receptor.

W-54011 (3-30 mg/kg; oral administration; for 4 hours; male mongolian gerbils) treatment inhibited C5a-induced neutropenia in a dose-dependent manner in gerbils.
The species selectivity of W-54011 is examined in rhC5a-induced intracellular Ca 2+ mobilization of neutrophils in various species. The W-54011 is able to inhibit the response in cynomolgus monkeys and gerbils with IC 50 values of 1.7 nM and 3.2 nM, respectively, but not in mice, rats, guinea pigs, rabbits, and dogs.

Animal Model: Male mongolian gerbils (6-12 weeks) injected with rhC5a
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Oral administration; for 4 hours
Result: Inhibited C5a-induced neutropenia in a dose-dependent manner.

W-54011 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-16992A W-54011 405098-33-1 1mg 900
2024-01-25 HY-16992A W-54011 405098-33-1 5mg 1800

W-54011供应商 更多

武汉沃格达生物科技有限公司
现货
联系电话: 15071299552
产品介绍:
英文名称:W-54011
CAS:405098-33-1
纯度:98%
包装信息:mg;g;kg
库存量:257mg
现货日期:2024/3/29 9:14:09
上海一飞生物科技有限公司
联系电话:021-65675885 18964387627
产品介绍:
英文名称:W-54011
CAS:405098-33-1
纯度:99% (HPLC)
包装信息:1mg;5mg;10mg
备注:试剂级
北京索莱宝科技有限公司
联系电话:010-50973185 4009686088
产品介绍:
英文名称:W-54011
CAS:405098-33-1
上海氟德化工有限公司
联系电话:021-54450827 021-54450828
产品介绍:
英文名称:N-[[4-(dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-Naphthalenecarboxamide Hydrochloride
CAS:405098-33-1
纯度:97%
包装信息:1g/;5g/
上海源溪生物科技有限公司
联系电话:021-58447131 13564518121
产品介绍:
英文名称:W-54011
CAS:405098-33-1
纯度:98% HPLC
包装信息:100mg,250mg,1g

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