One of the numerous alkaloids which have been isolated from Vinca rosea L.
(Syn. Catharanthus roseus G. Don.), this base yields colourless crystals from
MeOH and is strongly laevorotatory with [α]D - 528° (CHCl3) or [α]27D - 432°
(CHCI3). The ultraviolet spectrum of the alkaloid in EtOH shows three absorption maxima at 226, 297 and 327 ffi/.l. The suggested structure contains one
methoxycarbonyl group, an imino group, a bridge ethyl group and an epoxy
ring. The second nitrogen atom is tertiary.
ChEBI: Lochnericine is an Aspidosperma alkaloid with molecular formula C21H24N2O3 found in the roots of Madagascar periwinkle (Catharanthus roseus, formerly known as Vinca rosea). It has a role as a plant metabolite. It is a monoterpenoid indole alkaloid, an organic heterohexacyclic compound, a methyl ester, an epoxide and an Aspidosperma alkaloid. It is a conjugate base of a lochnericine(1+).
Nair, Pillay., Tetrahedron, 6,89 (1959)
Gorman et at., J. Amer. Pharm. Assoc., Sci. Ed., 48, 256 (1959)
Moza, Trojanck., Chem. Ind., 1425 (1962)
Mozaetat., Tetrahedron Lett., 2561 (1964)
