扁塑藤素
扁塑藤素 性质
| 熔点 | 219.5°C |
|---|---|
| 沸点 | 488.1°C (rough estimate) |
| 密度 | 1.0271 (rough estimate) |
| 折射率 | 1.4800 (estimate) |
| 储存条件 | -20°C |
| 溶解度 | 二甲基亚砜：≥5mg/mL |
| 形态 | 红色固体 |
| 酸度系数(pKa) | 8.60±0.70(Predicted) |
| 颜色 | 橙色 |
| InChIKey | JFACETXYABVHFD-VXTIGNJVNA-N |
| SMILES | [C@]12(C)CC[C@@]3(C)CC[C@@](C)(C(=O)OC)C[C@@]3([H])[C@]1(C)CC[C@@]1(C)C3=CC(C(O)=C(C)C3=CC=C21)=O |&1:0,4,8,15,17,21,r| |
扁塑藤素 用途与合成方法
IC50: 93 nM (MGL)
Pristimerin inhibits the activity of purified MGL with an IC 50 of 93±8 nM and that of non-purified MGL (cell lysates of MGL-transfected HeLa cells) with an IC 50 of 398±68 nM. Pristimerin inhibits MGL through a mechanism that is rapid, reversible and non-competitive. The binding of pristimerin to MGL might be strengthened by formation of a polar interaction with a regulatory cysteine, possibly Cys 208 . Pristimerin inhibits HFLS-RA and HUVEC cell viability in a dose- and time-dependent manner. Pristimerin decreases VEGF-induced autophosphorylation of VEGFR2 and attenuates the activation of the VEGF-induced VEGFR2-mediated signaling pathway .
Pristimerin inhibits inflammation and tumor angiogenesis. Pristimerin significantly reduces vessel density in synovial membrane tissues of inflamed joints and reduces the expression of pro-angiogenic factors in sera, including TNF-α, Ang-1, and MMP-9.
扁塑藤素 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-N1937 | 扁塑藤素 | 1258-84-0 | 1 mg | 316 |
| 2026-09-15 | HY-N1937 | 扁塑藤素 | 1258-84-0 | 5mg | 748 |
