Adipic dihydrazide

141-28-6

1071-93-8

General method: 7.6 g (100.0 mmol) of solid hydrazine (H3N + NHCO2-) was mixed with adipic acid (7.3 g, 50.0 mmol) in a mortar and pestle under solvent-free conditions for 10 min, followed by a stirring reaction for 5 h at 100 °C. The structure and composition of the reaction products were confirmed by 400 MHz NMR (nuclear magnetic resonance) and elemental analysis. The analysis showed that the product was hexanedihydrazide (C6H14N4O2) with ≥96% conversion and ≥95% yield (8.27 g). Alternative method: 10 g of decane was used as solvent and the reaction conditions were adjusted to stirring at 110 °C for 12 h, followed by filtration and separation operations. The rest of the steps were the same as in the generalized method. The product was analyzed as hexanedihydrazide (C6H14N4O2) with 97% conversion and 93% yield. Substitution: 5.0 g (100.0 mmol) of hydrazine hydrate was used in place of the solid hydrazine and 10.12 g (100.0 mmol) of diethyl adipate was used in place of adipic acid. The reaction was stirred at 75 °C for 5 h under the condition of 10 g ethanol as solvent. The product was analyzed as hexanedihydrazide (C6H14N4O2) with 89% conversion and 83% yield.