2-Pyrimidinamine, 5-methyl- (9CI)

22536-61-4

50840-23-8

Step 1: 2-Chloro-5-methylpyrimidine (10.0 g, 77.79 mmol) was dissolved in industrial methanol (IMS, 100 mL) followed by addition of 35% ammonia (100 mL). The reaction mixture was transferred to an autoclave, sealed and reacted at 200 °C for 4 hours. Upon completion of the reaction, it was cooled to room temperature and most of the solvent was removed by concentration via rotary evaporator. Water (25 mL) was added to the residue and a solid was precipitated. The solid was collected by filtration and dried under vacuum to afford 2-amino-5-methylpyrimidine (7.85 g, 92% yield) as an off-white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.06 (s, 2H), 6.30 (s, 2H), 2.03 (s, 3H).LCMS analysis showed m/z 110 [M + H]+.