Peracon,Toyo Jozo,Japan,1969
140 cc of benzene and 24 g of α-isopropyl phenyl acetonitrile are added to 7.5
g of sodium amide. The mixture is stirred and refluxed for one hour. After
cooling, 25 g of 2-dimethylamino-1-chloropropane, dissolved in 20 cc of
benzene, are added and stirring and refluxing of the mixture is continued for
4 hours. After the reaction is completed, water is added to the reaction
mixture. The benzene layer is separated from the aqueous layer and is
extracted by means of 4N hydrochloric acid. The acid solution is rendered
alkaline.
The separated oil is taken up in ether. After drying the ethereal solution over
sodium sulfate and distilling off the ether, the resulting crude α-isopropyl-α- (β'-dimethylamino propyl) phenyl acetonitrile is purified by distillation in a
vacuum. The compound boils at 138° to 146°C/3 mm, according to US Patent
2,934,557.
