There are three isomers of nitrophenol. The
isomer of greatest concern, and the subject of ATSDR
Toxicology Profile, is the p-isomer (4-nitrophenol). The
meta-form is produced from m-nitroaniline, and the o-and
p-isomers are produced by nitration of phenol. They are
colorless to slightly yellowish crystals with an aromatic to
sweetish odor.
ChEBI: 2-nitrophenol is a member of the class of 2-nitrophenols that is phenol in which one of the hydrogens that is ortho to the hydroxy group has been replaced by a nitro group. It is a conjugate acid of a 2-nitrophenolate.
A yellow crystalline solid consisting of a mixture of chemically similar isomers. Slightly soluble in water. The primary hazard is the threat posed to the environment. Immediate steps should be taken to limit its spread to the environment. Nitrophenol is combustible though Nitrophenol may take some effort to ignite. Burns to give toxic oxides of nitrogen. Used in the manufacture of other chemicals.
Slightly soluble in water.
Organonitrate compounds, such as Nitrophenol, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases.
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
(p-isomer): Possible risk of forming
tumors, Suspected reprotoxic hazard. Nitrophenols are used
as intermediates in production of dyes; photochemicals,
pesticides, and pharmaceuticals; in leather tanning.
UN1663 Nitrophenols (o-; m-; p-), Hazard
Class: 6.1; Labels: 6.1-Poisonous materials.
Nitrophenols are strong oxidizers. Reacts
violently with combustible and reducing agents. Contact
with potassium hydroxide forms an explosive mixture. May
explode on heating.
Controlled incineration-care
must be taken to maintain complete combustion at all
times. Incineration of large quantities may require scrubbers
to control the emission of nitrogen oxides. In accordance
with 40CFR165, follow recommendations for the
disposal of pesticides and pesticide containers. Must be disposed
properly by following package label directions or by
contacting your local or federal environmental control
agency, or by contacting your regional EPA office. Consult
with environmental regulatory agencies for guidance on
acceptable disposal practices. Generators of waste containing
this contaminant (≥100 kg/mo) must conform with
EPA regulations governing storage, transportation, treatment,
and waste disposal.
