Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research[1].
in vivo
Protein deglycase DJ-1 against-1 (compound-23; 1 mg/kg; IP; pretreatment one hour; daily; for 4 days) significantly restores MPTP induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice[1].
Animal Model:
Wild-type male C57BL/6 mice at 8, 11-12 and 9-12 weeks; DJ-1-knockout male mice at 11-13 weeks[1]
Dosage:
1 mg/kg
Administration:
IP; pretreatment one hour; daily; for 4 days
Result:
Significantly restored MPTP (30 mg/kg; IP; One hour after injection) induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.
References
[1] Kazuko Takahashi-Niki, et al. DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease. DOI:10.1016/j.jphs.2015.01.010
![3,4,5-trimethoxy-N-[4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide Structure](/CAS/20180528/GIF/724737-74-0.gif)
