2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE

White Crystalline Solid

2-Chloro-1,3,2-benzodioxaphosphorin-4-one is used as a reagent:

• In the phosphorylation and phosphitylation of alcohols.
• In the formation of H-phosphonates which are commonly utilized in the synthesis of nucleotides.
• To synthesize nucleoside triphosphates by treating with acyl protected nucleoside.

Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs

2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is a reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. It is also reactive cyclic phosphitylating reagent involved in fast coupling rates and hydrolytic cleavage more readily compare to that of a acyclic analog.