Kazinol U is prenylated flavan isolated from an extract of Broussonetia kazinoki Sieb (paper mulberry) th at exhibits anti-melanogenic activity in mouse and human melanoma cells through the induction of AMPK and MAPK phosphorylation. Kazinol U inhibits tyrosinase activity and melanin synthesis through the reduction of MITF expression. It suppresses melanogenesis in a zebrafish model. Kazinol U displays phytoestrogenic and anti-inflammatory activities. Kazinol U exhibits cytoprotective activities against cytokine-induced apoptotic cell death.
