Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteinsviaAMPK activation[1].
Kazinol U is prenylated flavan isolated from an extract of Broussonetia kazinoki Sieb (paper mulberry) th at exhibits anti-melanogenic activity in mouse and human melanoma cells through the induction of AMPK and MAPK phosphorylation. Kazinol U inhibits tyrosinase activity and melanin synthesis through the reduction of MITF expression. It suppresses melanogenesis in a zebrafish model. Kazinol U displays phytoestrogenic and anti-inflammatory activities. Kazinol U exhibits cytoprotective activities against cytokine-induced apoptotic cell death.
Estrogen receptor | NF-kB | IkB | NO | NOS | IFN-γ | IL Receptor | IKK | Progestogen receptor
[1] Lim J, et al. Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMP kinase activation.Br J Pharmacol. 2019;176(5):737-750. DOI:
10.1111/bph.14560
