PF 4800567
PF 4800567 性质
| 沸点 | 592.9±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.52±0.1 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | DMF：25mg/mL； DMF:PBS(pH 7.2)(1:1)：0.5 mg/ml； DMSO：10mg/mL；乙醇：1mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 4.01±0.30(Predicted) |
| 颜色 | 浅黄至黄色 |
| InChI | 1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21) |
| InChIKey | AUMDBEHGJRZSOO-UHFFFAOYSA-N |
| SMILES | NC1=NC=NC2=C1C(COC3=CC=CC(Cl)=C3)=NN2C4CCOCC4 |
PF 4800567 用途与合成方法
| Target | Value |
|
casein kinase 1 epsilon
(Cell-free assay) | 32 nM |
|
casein kinase 1 delta
() | 711 nM |
PF-4800567 is a potent and selective inhibitor of casein kinase 1ϵ (CK1ϵ), with an IC 50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC 50 , 711 nM). PF-4800567 shows inhibitory activity against CK1ϵ and CK1δ in whole cells, with IC 50 s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1ϵ-mediated PER3 nuclear localization mediated by CK1ϵ and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 has little effect on the circadian clock at 32 nM.
PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice.
PF 4800567 is a selective casein kinase inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.
PF 4800567 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-12470 | 1188296-52-7 | 1 mg | 192 | |
| 2025-12-22 | HY-12470 | 3-((3-氯苯氧基)甲基)-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺 | 1188296-52-7 | 5mg | 477 |
