Tadalafil-d3

Tadalafil-d₃ is intended for use as an internal standard for the quantification of tadalafil by GC- or LC-MS. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC₅₀ = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC₅₀s = 9.2-280 μM), however, it does also inhibit PDE11 (IC₅₀ = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury. It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice. Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.

Tadalafil-d3 is White Solid

Tadalafil-d3 is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor. Intended for use as an internal standard for the quantification of Tadalafil by GC- or LC-mass spectrometry.

Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.

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[2] VANESSA DE FáTIMA LIMA PAIVA MEDEIROS. The renoprotective effect of oral Tadalafil pretreatment on ischemia/reperfusion injury in rats.[J]. Acta cirurgica brasileira, 2017, 32 2: 90-97. DOI: 10.1590/s0102-865020170201
[3] MICHAEL SEIMETZ. Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.[J]. PLoS ONE, 2015: e0129327. DOI: 10.1371/journal.pone.0129327