(D-ALA7)-ANGIOTENSIN I/II (1-7)
(D-ALA7)-ANGIOTENSIN I/II (1-7)
(D-ALA7)-ANGIOTENSIN I/II (1-7) 性质
密度 | 1.45±0.1 g/cm3(Predicted) |
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储存条件 | -15°C |
酸度系数(pKa) | 3.29±0.10(Predicted) |
形态 | 冻干粉 |
颜色 | 白色至类白色 |
水溶解性 | ≥ 29.1mg/mL in Water with gentle warming |
(D-ALA7)-ANGIOTENSIN I/II (1-7) 用途与合成方法
A-779 inhibits the effect of Ang-(1-7), which suppresses the proliferating cell nuclear antigen (PCNA) protein expression up-regulated by Ang II, but A-779 alone has no effect to induce proliferation and migration of VSMCs. Pretreatment with Ang-(1-7) significantly retards Ang II-induced inflammatory responses of VSMCs associated with up-regulated MCP-1, VCAM-1 and IL-1β expressions, and this effect of Ang-(1-7) is blocked by A-779. But A-779 alone has no effect to induce inflammatory response of VSMCs. Pretreatment VSMCs with Ang-(1-7) for 5 min significantly inhibits Akt and ERK1/2 phosphorylation induced by Ang II, and this effect is also blocked by A-779, but alone has no effect to induce phosphorylation of Akt and ERK1/2 in VSMCs.
Infusion of Ang(1-7) and A-779 (400 ng/kg/min, s.c.) alone or combined for 6 weeks does not prevent uterus atrophy or inhibit the body weight gain of OVX rats. A-779 markedly elevates serum bone specific alkaline phosphatase (BALP), telopeptides of collagen type I (CTX), tartarate resistant acid phosphatase (TRAcP 5b), osteocalcin (OC) and urinary deoxypyridinoline (DPD). Infusion of Ang(1-7) and/or A-779 does not significantly change serum minerals concentrations in sham or OVX groups. A-779 in the OVX animals does not change AngII, Ang(1-7), AT1R, AT2R, ACE, ACE-2, Mas receptor, RANKL and OPG proteins expressions in relation to OVX group, while AngII (P [1] . Inhibition of Ang1-7 cascade by A-779 (400 ng/kg/min) significantly eradicates captopril protective effects on bone metabolism, mineralization and micro-structure. A-779 also restores OVX effects on RANKL expression and ACE-1/AngII/AT1R cascade and down-regulates OPG expression and ACE-2/Ang1-7/Mas pathway.
(D-ALA7)-ANGIOTENSIN I/II (1-7) 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024-11-08 | A3281 | A-779 | 159432-28-7 | 25mg | 405 |
2024-11-08 | A3281 | A-779 | 159432-28-7 | 100mg | 1615 |