基本属性 生物活性体外研究体内研究 用途与合成方法 (D-ALA7)-ANGIOTENSIN I/II (1-7) 价格(试剂级) 供应商 供应信息 相关产品
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(D-ALA7)-ANGIOTENSIN I/II (1-7)

(D-ALA7)-ANGIOTENSIN I/II (1-7)

英文名称:(D-ALA7)-ANGIOTENSIN I/II (1-7)
CAS号:159432-28-7
分子式:C39H60N12O11
分子量:872.97
EINECS号:
Mol文件:159432-28-7.mol
(D-ALA7)-ANGIOTENSIN I/II (1-7) 结构式

(D-ALA7)-ANGIOTENSIN I/II (1-7) 性质

密度 1.45±0.1 g/cm3(Predicted)
储存条件 -15°C
酸度系数(pKa) 3.29±0.10(Predicted)
形态 冻干粉
颜色 白色至类白色
水溶解性 ≥ 29.1mg/mL in Water with gentle warming

(D-ALA7)-ANGIOTENSIN I/II (1-7) 用途与合成方法

A 779 是G蛋白偶联受体Mas的有效拮抗剂,Mas受体为一种Ang1-7 receptor,区别于传统的AngII。

A-779 inhibits the effect of Ang-(1-7), which suppresses the proliferating cell nuclear antigen (PCNA) protein expression up-regulated by Ang II, but A-779 alone has no effect to induce proliferation and migration of VSMCs. Pretreatment with Ang-(1-7) significantly retards Ang II-induced inflammatory responses of VSMCs associated with up-regulated MCP-1, VCAM-1 and IL-1β expressions, and this effect of Ang-(1-7) is blocked by A-779. But A-779 alone has no effect to induce inflammatory response of VSMCs. Pretreatment VSMCs with Ang-(1-7) for 5 min significantly inhibits Akt and ERK1/2 phosphorylation induced by Ang II, and this effect is also blocked by A-779, but alone has no effect to induce phosphorylation of Akt and ERK1/2 in VSMCs.

Infusion of Ang(1-7) and A-779 (400 ng/kg/min, s.c.) alone or combined for 6 weeks does not prevent uterus atrophy or inhibit the body weight gain of OVX rats. A-779 markedly elevates serum bone specific alkaline phosphatase (BALP), telopeptides of collagen type I (CTX), tartarate resistant acid phosphatase (TRAcP 5b), osteocalcin (OC) and urinary deoxypyridinoline (DPD). Infusion of Ang(1-7) and/or A-779 does not significantly change serum minerals concentrations in sham or OVX groups. A-779 in the OVX animals does not change AngII, Ang(1-7), AT1R, AT2R, ACE, ACE-2, Mas receptor, RANKL and OPG proteins expressions in relation to OVX group, while AngII (P [1] . Inhibition of Ang1-7 cascade by A-779 (400 ng/kg/min) significantly eradicates captopril protective effects on bone metabolism, mineralization and micro-structure. A-779 also restores OVX effects on RANKL expression and ACE-1/AngII/AT1R cascade and down-regulates OPG expression and ACE-2/Ang1-7/Mas pathway.

安全信息

海关编码2933.29.4300

(D-ALA7)-ANGIOTENSIN I/II (1-7) 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 A3281 A-779 159432-28-7 25mg 405
2024-11-08 A3281 A-779 159432-28-7 100mg 1615

(D-ALA7)-ANGIOTENSIN I/II (1-7)供应商 更多

成都云希化工有限公司
现货
联系电话:+86-17380623303 +86-17380623303
产品介绍:
英文名称:A-779
CAS:159432-28-7
纯度:95%
包装信息:1G; 10G; 100G
备注:企业级
库存量:>1g
现货日期:2024/11/20 11:42:42
杭州肽佳生物科技有限公司
现货
联系电话:0571-87213919
产品介绍:
英文名称:A-779
CAS:159432-28-7
纯度:98%
包装信息:1g;5g;10g;50g;100g,1000g or according to customer's detail requirement.
备注:1g
库存量:1g
现货日期:2024/11/15 9:30:07
吉尔生化(上海)有限公司
联系电话:21-61263452 13641803416
产品介绍:
英文名称:(D-Ala7)-Angiotensin I/II (1-7)
CAS:159432-28-7
纯度:95% HPLC,98% HPLC
包装信息:10mg, 25mg, 50mg, 100mg, 500mg, 1g,10g
南京康满林化工实业有限公司
联系电话:025-83697070
产品介绍:
中文名称:5-L-异亮氨酸-7-D-丙氨酸-1-7-血管紧缩素 II
英文名称:5-L-Isoleucine-7-D-alanine-1-7-angiotensin II
CAS:159432-28-7
纯度:98%
包装信息:5KG; 1KG
备注:490/25毫克;定制
上海瀚鸿科技股份有限公司
联系电话:021-54306202 13764082696
产品介绍:
英文名称:(D-Ala7)-Angiotensin I/II (1-7)
CAS:159432-28-7
备注:6P30

最新发布供应信息

(D-Ala7)-Angiotensin I/II (1-7) 159432-28-7
宝鸡缔都医药化工有限公司 2024-11-25
拮抗剂多肽A-779/159432-28-7/上海鸿肽生物多肽合成
上海鸿肽生物科技有限公司 2024-11-16

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