GW501516
GW501516 性质
| 熔点 | 134-136°C |
|---|---|
| 沸点 | 584.5±60.0 °C(Predicted) |
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 在DMSO中的溶解度为20mg/mL，澄清 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 3.17±0.10(Predicted) |
| 颜色 | 白色至米色 |
| BRN | 18515150 |
| 稳定性 | 感光 |
| InChI | InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27) |
| InChIKey | YDBLKRPLXZNVNB-UHFFFAOYSA-N |
| SMILES | C(O)(=O)COC1=CC=C(SCC2SC(C3=CC=C(C(F)(F)F)C=C3)=NC=2C)C=C1C |
| CAS 数据库 | 317318-70-0 |
GW501516 用途与合成方法
| Target | Value |
|
PPARδ
(Cell-free assay) | 1 nM(Ki) |
GW 501516 is shown to be the most potent and selective PPARα agonists known with an EC 50 of 1.1 nM against PPARα and 1000-fold selectivity over the other human subtypes, PPARα and-γ. GW 501516 exerts anti-inflammatory effects in mouse cultured proximal tubular (mProx) cells. GW 501516 inhibits palmitate- and TNFα-induced increases in MCP-1 mRNA expression in a dose-dependent manner.
GW 501516 causes impaired bone formation, leading to decreased BMD and deterioration of bone properties in OVX rats. GW 501516 attenuates interstitial inflammation and proximal tubular cell damage in a protein-overload mouse nephropathy model. GW 501516 treatment enhances running endurance and the proportion of succinate dehydrogenase (SDH)-positive muscle fibres in both trained and untrained mice.
GW501516 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | S1473 | GW501516 | 317318-70-0 | 5mg | 2205.27 |
| 2024-11-08 | S1473 | GW501516 | 317318-70-0 | 25mg | 7945.88 |
