3'-叠氮基-2',3'-二脱氧-5-甲基胞苷
3'-叠氮基-2',3'-二脱氧-5-甲基胞苷 性质
| 储存条件 | 4°C, away from moisture |
|---|---|
| 溶解度 | DMSO：200 mg/mL（751.15 mM；需要超声） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
3'-叠氮基-2',3'-二脱氧-5-甲基胞苷 用途与合成方法
|
HIV-1 9 nM (EC 50 , Human PBM cells) |
HIV-1 6 nM (EC 50 , Human macrophages) |
AzddMeC (CS-92) is also effective against HIV-2 in lymphocytes. The replication of Friend murine virus is only weakly inhibited, and no effect is observed against HSV type 1 and type 2 and coxsackievirus B4. The interaction of the 5'-triphosphate of AzddMeC with HIV-1 reverse transcriptase indicated competitive inhibition (the inhibition constant, Kis, is 9.3 nM).
The pharmacokinetics of AzddMeC are characterized following intravenous and oral administration of 60 mg/kg of the compound to male rhesus monkeys. 3'-azido-3'-deoxythymidine (AZT) is a major metabolite of AzddMeC in monkeys. AzddMeC concentrations in serum declined rapidly in a biexponential fashion with the terminal half-life ranging from 0.5 to 1.3 hr. Renal excretion of unchanged nucleoside and metabolic deamination yielding AZT are the primary routes of AzddMeC clearance. The oral bioavailability is 26%.
3'-叠氮基-2',3'-二脱氧-5-甲基胞苷 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-08-19 | HY-105268 | 1 mg | 954 | ||
| 2024-08-19 | HY-105268 | 3'-叠氮基-2',3'-二脱氧-5-甲基胞苷 | 5 mg | 2100 |
