1. Fermentation: take sugar, ammonia homoserine as raw material, applying
producing Micrococcus glutamicus or Brevibacterium for fermentation, and then separate to get L-body and DL-body.
2. Casein, silk protein and sericin are subject to hydrolysis, and then ion
exchange resin purification to obtain the L-threonine.
3. glycine copper and acetaldehyde are taken as raw materials for reaction in
the alkaline medium to generate DL-body. L-seed is inoculated in DL-in vivo, and the L-form is obtained by resolving the anti-L-form.
4. take crotonic acid as raw material for reaction with ethoxy mercury,
potassium bromide and methanol, and further subject to demercuration, followed by ammoniation by ammonia, followed by acidification under the action of formic acid and acetic anhydride, and finally hydrolysis in hydrobromic acid to obtain the DL-body.
⑤ acetaldehyde is reacted with amino nitrile to obtain the DL-body.
⑥ take ethyl acetoacetate as raw material for reaction with aniline, followed by hydrogenation to produce threonine ethyl ester, and finally under the reaction of acetic anhydride and thionyl chloride, we can obtain DL-body.
Figure 2 is the chemical reaction route of DL-threonine produced from ethyl acetoacetate.
This information is compiled and edited by Xiao Nan of Chemicalbook.