C8 CERAMIDE

C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1?Induces apoptosis.2?Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver epithelial cells.3?C8-ceramide induces the secretion of brain-derived neurotrophic factor (BDNF) from microglia?in vitro.4

Off White Powder

A biologically active, cell permeable, but nonphysiologic ceramide analog. It induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. It stimulates IL-2 secretion and induces apoptosis

C-8 Ceramide is a ceramide analog.

ChEBI: N-octanoylsphingosine is an N-acylsphingosine in which the ceramide N-acyl group is specified as octanoyl. It is functionally related to an octanoic acid.

PKC; apoptosis; autophagy

[1] S MATHIAS  R N K  K A Dressler. Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1991, 88 22: 10009-10013. DOI:10.1073/pnas.88.22.10009
[2] W D JARVIS. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91 1: 73-77. DOI:10.1073/pnas.91.1.73
[3] BRAD L UPHAM . Differential roles of 2, 6, and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis[J]. Cancer letters, 2003, 191 1: Pages 27-34. DOI:10.1016/s0304-3835(02)00620-1
[4] KAZUYUKI NAKAJIMA. Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro[J]. Journal of Neurochemistry, 2002, 80 4: 697-705. DOI:10.1046/j.0022-3042.2001.00752.x