Gabapentin-lactam

Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic filopodia and inducing a network of F-actin-containing neurites in cultured hippocampal neurons.2 Promotes the survival of cultured central nervous system neurons possibly by opening mitochondrial KATP channels.3 Displays neuroprotective effects in a rat model of acute retinal ischemia.4

Gabapentin-lactam is White Solid

Gabapentin-lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.

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Gabapentin Lactam reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington disease. It opens mitochondrial ATP-dependent potassium channels

ChEBI: 2-Azaspiro[4.5]decan-3-one is an azaspiro compound.

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[1] BIRGIT ZUCKER. Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 2004, 370 2: 131-139. DOI:10.1007/s00210-004-0959-9
[2] FRANK HENLE. Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons.[J]. Journal of Pharmacology and Experimental Therapeutics, 2006, 319 1: 181-191. DOI:10.1124/jpet.106.106146
[3] AMELIE PIELEN. Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels.[J]. Graefe’s Archive for Clinical and Experimental Ophthalmology, 2004, 242 3: 240-244. DOI:10.1007/s00417-004-0872-4
[4] W. LAGRÈZE T F R Müller Velten. The neuroprotective properties of gabapentin-lactam[J]. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe’s archive for clinical and experimental ophthalmology, 2001, 239 1: 845-849. DOI:10.1007/s00417-001-0383-5