Basic information Description Mechanism of Action Safety Related Supplier
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BIBW2992 DiMaleate

Basic information Description Mechanism of Action Safety Related Supplier
BIBW2992 DiMaleate Basic information
Safety Information
  • HS Code 29339900
BIBW2992 DiMaleate Usage And Synthesis
  • Description

    Afatinib dimaleate (Tovok; BIBW2992; Gilotrif) is a salt form of Afatinib. Afatinib is a second-generation, orally administered, irreversible inhibitor of the ErbB family of tyrosine kinases.

  • Mechanism of Action

    Afatinib downregulates ErbB signalling by covalently binding to the kinase domains of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER) 2 and HER4, resulting in irreversible inhibition of tyrosine kinase autophosphorylation; it also inhibits transphosphorylation of HER3. Afatinib is approved as monotherapy for the treatment of EGFR tyrosine kinase inhibitor (TKI)-naïve adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating EGFR mutations in the EU, and for the first-line treatment of patients with metastatic NSCLC whose tumours have EGFR exon 19 deletions or exon 21 (L858R) substitution mutations as detected by a US FDA-approved test in the US.

  • DefinitionChEBI: A maleate salt obtained by combining afatinib with two molar equivalents of maleic acid. Used for the first-line treatment of patients with metastatic non-small cell lung cancer.
BIBW2992 DiMaleate(850140-73-7)Related Product Information
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  • Company Name:WuHu Linze pharmaceutical Co.,Ltd. Gold
  • Tel:18356571950
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