Furowanin A

Furowanin A shows significant cytotoxicity against HL-60 cells. Furowanin A induces that Caspase-9 and caspase-3 inhibitors suppresses apoptosis.

Furowanin A is a flavonoid with anti-neoplastic effects. Furowanin A inhibits STAT3/Mcl-1 axis to suppress proliferation, block cell cycle progression, induce apoptosis and promote autophagy. Furowanin A potently inhibits colorectal cancer (CRC) cells[1].

Caspase

Mcl-1; STAT3

[1] Ma Z, et al. Furowanin A-induced autophagy alleviates apoptosis and promotes cell cycle arrest via inactivation STAT3/Mcl-1 axis in colorectal cancer. Life Sci. 2019 Feb 1;218:47-57. DOI:10.1016/j.lfs.2018.12.027