BAY38-7271
BAY38-7271 性质
| 沸点 | 527.2±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.350±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 酸度系数(pKa) | 14.81±0.10(Predicted) |
BAY38-7271 用途与合成方法
|
CB1 1.85 nM (Ki) |
CB2 5.96 nM (Ki) |
BAY 38-7271 shows only minor interactions at the micromolar range with other binding sites such as adenosine A
3
receptor (IC
50
= 7.5 μM), peripheral GABA
A
benzodiazepine receptor (IC
50
= 971 nM), melatonin ML
1
receptor (IC
50
= 3.3 μM), and at the monoamine transporter (IC
50
= 1.7 μM).
BAY 38-7271 (Ed
50
= 0.02 mg/kg; i.v. and 0.5 mg/kg; i.p.) induces a potent and dose-de-pendent reduction in core body temperature.
BAY 38-7271 has low physical dependence liability and is not essentially different from that of other cannabinoid CB
1
receptor agonists.
BAY 38-7271 (1-1000 ng/kg/h; i.v. infusion; for 4 hours) shows neuroprotective efficacy in the rat SDH model.
BAY 38-7271 also has neuroprotective efficacy in models of transient and permanent occlusion of the middle cerebral artery and brain edema models.
| Animal Model: | Wistar rat ,TBI rat models (acute subdural hematoma, SDH) |
| Dosage: | 1 ng/kg/h, 10 ng/kg/h, 100 ng/kg/h, 1000 ng/kg/h |
| Administration: | Intravenous infusion, for 4 hours |
| Result: | Reduced the mean infarct volume. |
BAY38-7271 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2023-03-20 | HY-119744 | BAY38-7271 | 212188-60-8 | 5mg | 5800 |
| 2023-03-20 | HY-119744 | BAY38-7271 | 212188-60-8 | 10mg | 9800 |
