viscumneoside III

Viscumneoside III, a dihydroflavone O-glycoside, is a potent tyrosinase inhibitor with an IC50 of 0.5 mM. Viscumneoside III has anti-angina pectoris[1].

ChEBI: A viscumneoside that is homoeriodictyol in which the hydroxy group at position 7 has been converted to the corresponding beta-D-glucopyranoside, the 2-hydroxy group of which has been converted to its beta- stereo>D-apiofuranoside derivative. Found in Viscum coloratum, an evergreen hemiparasitic plant whose stems and leaves are used in traditional Chinese medicine for the treatment of rheumatism.

[1] LeiZou, et al. Total synthesis of viscumneoside III of Viscum coloratum. Tetrahedron,Volume 74, Issue 19, 10 May 2018,Pages 2376-2382.
[2] Se-Hui Jung, et al. Velutin, an Aglycone Extracted from Korean Mistletoe, with Improved Inhibitory Activity against Melanin Biosynthesis. Molecules. 2019 Jul 12;24(14):2549. DOI:10.3390/molecules24142549