Eflornithine hydrochloride hydrate

Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1Induces apoptosis in a variety of cells.2Difluoromethylornithine HCl displays cancer chemopreventive activity.3Cell permeable. Active in vivo.

White Solid

Eflornithine hydrochloride hydrate is irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism.

ChEBI: Eflornithine hydrochloride monohydrate is the hydrochloride and hydrate of the trypanocidal drug eflornithine. It is a hydrochloride and a hydrate. It contains an eflornithine.

Ornidyl (Sanofi Aventis); Vaniqa (Skinmedica).

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

Primary TargetODC

[1] VERMA A K. Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.[J]. Basic life sciences, 1990, 52: 195-204. DOI:10.1007/978-1-4615-9561-8\_16
[2] Y TAKAHASHI  K N  M Mai. alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model.[J]. International Journal of Cancer, 2000, 85 2: 243-247.
[3] F L MEYSKENS  E W G. Development of difluoromethylornithine (DFMO) as a chemoprevention agent.[J]. Clinical Cancer Research, 1999, 5 5: 945-951.