N-Boc-endo-3-aminotropane

207405-67-2

207405-68-3

TERT-BUTYL (1R,3R,5S)-3-(BENZYLAMINO)-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE (Compound 3b, 7.0 g, 22.2 mmol) was used as a raw material, which was mixed with ammonium formate (7.0 g, 111 mmol) and 20% palladium hydroxide /carbon catalyst (0.7 g) in ethanol (200 ml). The reaction mixture was stirred at 50°C for 2 hours. After completion of the reaction, it was cooled to room temperature and the catalyst was removed by filtration. The filtrate was concentrated by rotary evaporation and purified by column chromatography to afford the target product tert-butyl endo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate (Compound 3c, 4.7 g, 94% yield).