Soluble in methanol, ethanol, DMSO and other organic solvents, derived from the aerial part of Equisetum, Rhodiola rosea.
Herbacetin is a flavonol compound, and a natural inhibitor of E.coli β-glucuronidase. Herbacetin inhibits inducible nitric oxide synthase via JNK and nuclear factor-κB in LPS-stimulated RAW264.7 cells. Molecular docking study of flavonoid compounds as an inhibitor of β-ketoacyl acyl carrier proteinsynthase II of Pseudomonas aeruginosa.
ChEBI: Herbacetin is a pentahydroxyflavone that is kaempferol substituted by a hydroxy group at position 8. It is a natural flavonoid from flaxseed which exerts antioxidant, anti-inflammatory and anticancer activities. It has a role as an EC 4.1.1.17 (ornithine decarboxylase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, a plant metabolite, an antilipemic drug, an anti-inflammatory agent and an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor. It is a pentahydroxyflavone and a 7-hydroxyflavonol. It is functionally related to a kaempferol.
Herbacetin is a natural flavonoid in flaxseed with a variety of pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Gluprotamine is an allosteric inhibitor of Ornithine decarboxylase (ODC), which directly binds to Asp44, Asp243 and Glu384 on ODC.
Method of extracting Herbacetin from Rhodiola rosea, comprising the following steps;
1) extracting crushed Rhodiola rosea herbs with an extraction solvent, and concentrating the extract under reduced pressure to obtain an extract infusion;
2) extract the extract extract, the extracted aqueous layer and then acid hydrolysis;
3) The solution after acid hydrolysis is extracted with organic solvent, the extract is combined and concentrated under reduced pressure to obtain herbaceous extract;
4) the oxalic acid extract is processed by polyamide column chromatography, the stream fraction containing oxalic acid is collected, concentrated to dryness, and the crude oxalic acid is obtained;
5) The crude herbaceous material was processed by reversed-phase silica gel column chromatography, the flow fraction containing herbaceous material was collected, concentrated to dryness, and recrystallized to obtain the pure product of herbacetin material.
Herbacetin (orally administration; 20mg/kg) significantly reduces the body weight, plasma glucose, plasma insulin, and HOMA-IR activity in obesity associated insulin resistant mice (OIR). (Herbacetin dissolves in 0.5% DMSO) .Herbacetin (intraperitoneal injection; 0.4, 2, 10 or 20 mg/kg; BW) decreases the number and size of polyps in APCM in+ mice with no overt toxicity.
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