Hodgkinsine B

Hodgkinsine B is an alkaloid and isomer of hodgkinsine that has analgesic activity.1 It increases the latency to tail withdrawal in the tail-flick test in mice when administered at a dose of 10 mg/kg.

1.Kodanko, J.J., Hiebert, S., Peterson, E.A., et al.Synthesis of all low-energy stereoisomers of the tris(pyrrolidinoindoline) alkaloid hodgkinsine and preliminary assessment of their antinociceptive activityJ. Org. Chem.72(21)7909-7914(2007)