2-Cyclopentyl-2-hydroxy-2-phenylacetic Acid is an impurity of Glycopyrrolate (G657000), a novel pharmaceutical compound based on PDE IV inhibitors; used in the treatment of respiratory complaints. It is used in the synthesis of muscarinic M3 receptor antagonists.
intermediate for Glycopyrronium Bromide, Oxyphencyclimine HCl, Oxypyrronium Bromide
Resolving racemic alpha-cyclopentylmandelic acid by a chemical resolution method by using L-Tyrosine methyl ester and (R)-alpha-phenylethylamine as resolution reagents to respectively prepare (S)-alpha-cyclopentylmandelic acid and (R)-alpha-cyclopentylmandelic acid; and carrying out esterification reaction to respectively obtain chiral intermediates (S)/(R)-alpha-cyclopentylmethyl mandelate. Multistage enantioselective liquid-liquid extraction (ELLE) of α--cyclopentyl-mandelic acid (α-CPMA) enantiomers using hydroxyethyl-β-cyclodextrin (HE-β-CD) as extractant was studied in a cascade of centrifugal contactor separators (CCSs)[1].
[1] Panliang Zhang. “Study on enantioseparation of α-cyclopentyl-mandelic acid enantiomers using continuous liquid-liquid extraction in centrifugal contactor separators: Experiments and modeling.” Chemical Engineering and Processing - Process Intensification 107 (2016): Pages 168-176.
