4-Chloromandelic acid has been used as a catalyst for Michael Addition of 2-(1-Ethylpropoxy)acetaldehyde to N-[(1Z)-2-Nitroethenyl]acetamide. As well, it has been used as a nucleation inhibitor for dutch resolution for diastereomers of racemic 3-methoxyphenylethylamine with chiral mandelic acid.
4-chloro mandelic acid, has R type and S type two kinds of enantiomorph configurations, is all widely used in multiple fields such as medicine production, asymmetric synthesis, optical resolution.
4-Chloromandelic acid causes skin irritation and serious eye irritation.
4-chloromandelic acid and the chiral resolution agent (R)-(+)-1-(1-naphthyl)ethylamine react in a suitable alcohol solvent to generate (R)-(+)-1-(1-naphthyl)ethylamine salt of the 4-chloromandelic acid, by using different solubilities of an enantiomer salt, crystallizing and suction filtration are performed to obtain the (R)-(+)-1-(1-naphthyl)ethylamine salt of the (R)-(-)-4-chloromandelic acid.
