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Bilobalide

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Bilobalide Basic information
Bilobalide Chemical Properties
  • Melting point:>300°
  • alpha 57820 -64.3° (c = 2 in acetone)
  • Boiling point:651.7±55.0 °C(Predicted)
  • Density 1.56±0.1 g/cm3(Predicted)
  • storage temp. −20°C
  • pka11.74±0.40(Predicted)
  • form neat
  • Merck 14,1220
  • CAS DataBase Reference33570-04-6(CAS DataBase Reference)
Safety Information
  • Safety Statements 24/25
  • WGK Germany 3
  • RTECS LV1665000
  • 10
  • HS Code 29322090
Bilobalide Usage And Synthesis
  • DefinitionChEBI: A terpenoid trilactone found in extracts of Ginkgo biloba.
  • Enzyme inhibitorThis plant natural product (FW = 326.30 g/mol; CAS 33570-04-6) from the gingko tree (Ginkgo biloba) is a terpene trilactone that exhibits anticonvulsant properties. Bilobalide has multiple mechanisms of action (e.g., acting as a GABAA receptor antagonist (/1), preserving mitochondrial ATP synthesis, inhibiting staurosporine-induced apoptotic damage, suppressing hypoxia-induced membrane deterioration in the brain, and increasing the expression the mitochondrial DNA-encoded COX III subunit of cytochrome c oxidase and the ND1 subunit of NADH dehydrogenase). Bilobalide was later synthesized in E. J. Corey’s laboratory in the late 1980s.
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