Bilobalide
- Product Name:Bilobalide
- CAS:33570-04-6
- MF:C15H18O8
- MW:326.3
- EINECS:
- Mol File:33570-04-6.mol
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Bilobalide Chemical Properties
- Melting point:>300°
- alpha 57820 -64.3° (c = 2 in acetone)
- Boiling point:651.7±55.0 °C(Predicted)
- Density 1.56±0.1 g/cm3(Predicted)
- storage temp. −20°C
- pka11.74±0.40(Predicted)
- form neat
- Merck 14,1220
- CAS DataBase Reference33570-04-6(CAS DataBase Reference)
Bilobalide Usage And Synthesis
- DefinitionChEBI: A terpenoid trilactone found in extracts of Ginkgo biloba.
- Enzyme inhibitorThis plant natural product (FW = 326.30 g/mol; CAS 33570-04-6) from the gingko tree (Ginkgo biloba) is a terpene trilactone that exhibits anticonvulsant properties. Bilobalide has multiple mechanisms of action (e.g., acting as a GABAA receptor antagonist (/1), preserving mitochondrial ATP synthesis, inhibiting staurosporine-induced apoptotic damage, suppressing hypoxia-induced membrane deterioration in the brain, and increasing the expression the mitochondrial DNA-encoded COX III subunit of cytochrome c oxidase and the ND1 subunit of NADH dehydrogenase). Bilobalide was later synthesized in E. J. Corey’s laboratory in the late 1980s.
- Whiskey lactone 3-isopropylglutaric acid 5,5-DIETHOXYPENTAN-1-OL Ethylidene diacetate ALPHA,ALPHA-DIMETHYL-GAMMA-BUTYROLACTONE 2-HYDROXY-CYCLOPENTANECARBOXYLIC ACID METHYL ESTER (TETRAHYDRO-FURAN-3-YL)-ACETIC ACID TETRAHYDRO-3-FUROIC ACID METHYL TUBERATE methyl 3-(acetoxy)octanoate 2,2-Dimethylglutaric acid 1,1-dimethoxy-3,7-dimethyloctane 2-propylpentanal dimethyl acetal Bilobalide 3-ETHYL-3-METHYLGLUTARIC ACID D-(-)-PANTOLACTONE (+)-3-METHYLHEXANEDIOIC ACID DL-3-ACETOXYBUTYRIC ACID ETHYL ESTER
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