E1R 性质
沸点 | 480.0±45.0 °C(Predicted) |
---|---|
密度 | 1.168±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:60 mg/ml(258.31 mM) |
酸度系数(pKa) | 15.67±0.40(Predicted) |
形态 | 固体 |
颜色 | 浅黄至黄色 |
E1R 用途与合成方法
E1R 是一种 sigma-1 受体的正变构调节剂 (Sig1R PAM),具有认知增强效果。
The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([ 3 H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells.
E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10 mg/kg; administered i.p. 60 min before the training session) significantly improves cognitive function in a dose-related manner in mice.
Animal Model: | Male ICR and Balb/c mice weighed 23-25 g |
Dosage: | 0.1, 1 and 10 mg/kg |
Administration: | Administered i.p. 60 min before the training session |
Result: | Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group. |
E1R 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-04-30 | HY-116463 | 1 mg | 1200 | ||
2024-04-30 | HY-116463 | E1R | 1301211-78-8 | 5mg | 3000 |
E1R供应商 更多
ChemeGen 中国
联系电话: 18818260767
产品介绍:
英文名称:E1R
CAS:1301211-78-8
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
英文名称:E1R
CAS:1301211-78-8
纯度:98%
包装信息:5mg;10mg;25mg;50mg;100mg
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 T10093L
英文名称:E1R;E1R,E-1R
CAS:1301211-78-8
纯度:98%
包装信息:100 mg;25 mg;50 mg