3-Fluoro-4-methylanisole is a nucleophilic, ring substituted electron acceptor that can be activated by electron donors. The nitro group and the electron donating substituents on the ring are important for this reactivity. 3-Fluoro-4-methylanisole can form substitution products with methyl or formyl groups in the presence of a strong base such as palladium, 3-fluoro-4-methylphenol, or nitro groups. This reactivity is regiospecific, meaning that the substitution will only occur at one of two possible sites on the ring. 3-Fluoro-4-methylanisole's chemical properties give it both activating and deactivating properties in organic reactions.
