Amidosulfuron

Amidosulfuron is a broad spectrum herbicide that is used to control broad-leaved weeds. It is volatile, highly soluble in water and, based on its chemical properties, has a high potential for leaching to groundwater. It is not persistent in soil systems but may be persistent in water under certain conditions.

Amidosulfuron has a low mammalian toxicity and would not be expected to bioaccumulate. Amidosulfuron is moderately toxic to most terrestrial and aquatic species.

Amidosulfuron, is used as pesticide and herbicides.

Herbicide.

ChEBI: Amidosulfuron is an aromatic ether.

The production of amidosulfuron involves a multi-step chemical synthesis. The key step includes reacting (N-methylsulfonyl-N-methylamino)sulfonamide with phenyl 4,6-dimethoxy-2-pyrimidylcarbamate in acetonitrile at room temperature for 18 hours. After partial solvent removal, water is added at 0 DegC, and the mixture is acidified to pH 2–3 using hydrochloric acid, prompting precipitation of the product. The solid is then filtered and washed, yielding amidosulfuron with high purity.

Selective, systemic absorbed through leaves and roots. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS

The hydrolysis of 14C-amidosulfuron in buffer aqueous solutions under various conditions results in 2-amino- 4,6-dimethoxypyrimidine as the major hydrolyzed product. In soils, O-demethylated amidosulfuron is the major degradation product. In mammals and plants, primary hydroxylation at the pyrimidine ring is a characteristic degradation reaction yielding 5-hydroxyamidosulfuron.

Herbicide