BOC-VAL-GLY-OH

51803-69-1

45233-75-8

GENERAL METHOD: Methyl tert-butoxycarbonyl-L-valylaminoacetate (2.6 g, 10 mmol) was dissolved in 50 mL of methanol, 1 M NaOH solution (30 mL) was added, and the reaction was stirred for 3 h at room temperature. Upon completion of the reaction, the solvent was removed by vacuum evaporation and the residue was adjusted to pH 2-3 with 1 M HCl. Subsequently, the mixture was extracted three times with EtOAc, the organic phases were combined and dried with anhydrous Na2SO4. Finally, the EtOAc was evaporated to afford the target compound 10a as a white solid in 92.4% yield.