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Bupivacaine hydrochloride

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Bupivacaine hydrochloride Basic information
Bupivacaine hydrochloride Chemical Properties
Safety Information
  • Hazard Codes T+
  • Risk Statements 26/27/28
  • Safety Statements 22-36/37/39-45
  • RIDADR UN 2811 6.1/PG 2
  • WGK Germany 3
  • RTECS TK6125000
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 2933399090
  • ToxicityLD50 in mice (mg/kg): 7.8 i.v., 82 s.c. (Henn, Brattsand)
Bupivacaine hydrochloride Usage And Synthesis
  • Chemical PropertiesWhite Solid
  • Usesantineoplastic
  • UsesSodium channel blocker, local anesthetic
  • brand nameMarcaine (Hospira); Sensorcaine (AstraZeneca).
  • Biological FunctionsBupivacaine hydrochloride (Marcaine, Sensorcaine) has particularly long action, and some nerve blocks last more than 24 hours; this is often an advantage for postoperative analgesia. Its use for epidural anesthesia in obstetrics has attracted interest because it can relieve the pain of labor at concentrations as low as 0.125% while permitting some motor activity of abdominal muscles to aid in expelling the fetus. The lower concentration minimizes the possibility of cardiac toxicity. Fetal drug concentrations remain low, and drug-induced neurobehavioral changes are not observed in the newborn. Bupivacaine also is approved for spinal anesthesia and is approximately four times more potent and more toxic than mepivacaine and lidocaine. It can be used with or without epinephrine.
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