Nomegestrol acetate (50, 100, 200 mg/kg; p.o.; single daily for 28 days) inhibits growth of RL95-2 xenograft tumors in vivo[1].
Nomegestrol acetate (100, 200 mg/kg; p.o.; single daily for 28 days) surpresses the expression of SUFU and Wnt7a in tumor tissues[1].
Nomegestrol acetate (1, 2.5 mg/rat; p.o.; single daily for 4 days) inhibits ovulation in rats[2].
| Animal Model: | Female athymic nude mice (BALB/c; 18-20 g; 6 to 7-week-old; xenograft nude mouse model)[1]. |
| Dosage: | 50, 100, 200 mg/kg |
| Administration: | Oral gavage; single daily for 28 days |
| Result: | Reduced the growth of RL95-2 xenograft tumors in vivo.
Upregulated the expression of SUFU and Wnt7a in a dose-dependent manner when at 100 and 200 mg/kg.
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| Animal Model: | Mature female Wistar rats (~200 g)[2]. |
| Dosage: | 1, 2.5 mg/rat |
| Administration: | Oral administration; single daily for 4 days |
| Result: | Showed only one animal ovulated after receiving 1 mg/kg per day, and no animals ovulated after receiving 2.5 mg/rat per day. |
