诺美林草酸盐
诺美林草酸盐 性质
| 熔点 | 148-150℃ |
|---|---|
| 储存条件 | Desiccate at +4°C |
| 溶解度 | DMF：1.6mg/mL； DMF:PBS (pH 7.2) (1:9)：0.1 mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
诺美林草酸盐 用途与合成方法
muscarinic receptor
Xanomeline stimulates phosphoinositide (PI) hydrolysis in the A9 L m1 cells.
Xanomeline inhibits [
3
H]-pirenzepine ([
3
H]-PZ) and [
3
H]-
oxotremorine
-M ([
3
H]-OXO-M) binding to rat brain with K
i
s of 7 and 3 nM, respectively.
Xanomeline robustly stimulates in vivo PI hydrolysis and the effect is blocked by muscarinic antagonists, demonstrating mediation by muscarinic receptors. In mice the ED 100 for Xanomeline-induced stimulation of [ 3 H]-IP accumulation is 54 μmole/kg in hippocampus. And in rats the ED 100 for Xanomeline-induced stimulation of [ 3 H]-IP accumulation is 8.1 μmole/kg in hippocampus.
| Animal Model: | Male CF1 mice weighing 18-20 g are injected [ 3 H]-myoinositol |
| Dosage: | 8.1-81 μmole/kg |
| Administration: | S.c. injections; 1 h prior to killing and 1 h after the administration |
| Result: | Increased accumulation in a dose-related manner up to 130%, 75%, 60% above lithium levels in hippocampus, cortex and neostriatum, respectively. And did not increase accumulation of [ 3 H]-IP in the brain stem. Induced salivation, tremor and hypothermia in mice with the ED 50 of 13.7±0.8 μmole/kg. |
| Animal Model: | Rats are injected [ 3 H]-myoinositol |
| Dosage: | 2.7-81 μmole/kg |
| Administration: | S.c. injections; 1 h prior to killing and 1 h after the administration |
| Result: | Increased [ 3 H]-IP formation dose dependently in hippocampus up to 221% above lithium control. |
诺美林草酸盐 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-13410 | 1 mg | 290 | ||
| 2024-11-08 | HY-13410 | 诺美林草酸盐 | 141064-23-5 | 5mg | 700 |
