1-Myristoyl-sn-glycero-3-phosphoethanolamine

1-Myristoyl-2-hydroxy-sn-glycero-3-PE is a naturally occurring lysophospholipid. It induces transient increases in intracellular calcium in PC12 cells. Serum levels of 1-myristoyl-2-hydroxy-sn-glycero-3-PE are elevated in patients with malignant breast cancer compared to healthy controls.

1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine is used in the method for diagnosis of lyme arthritis, method for differential diagnosis of lyme arthritis, lysophosphatidylethanolamine for use as biomarker, kit for diagnosis of lyme arthritis and kit for differential diagnosis of lyme arthritis.

ChEBI: 1-myristoyl-sn-glycero-3-phosphoethanolamine zwitterion is a 1-acyl-sn-glycero-3-phosphoethanolamine zwitterion obtained by transfer of a proton from the amino to the phosphate group of 1-myristoyl-sn-glycero-3-phosphoethanolamine; major species at pH 7.3. It is a 1-acyl-sn-glycero-3-phosphoethanolamine zwitterion, a lysophosphatidylethanolamine zwitterion 14:0 and a tetradecanoate ester. It is a tautomer of a 1-myristoyl-sn-glycero-3-phosphoethanolamine.

[1] T. MORE. Comprehensive quantitative lipidomic approach to investigate serum phospholipid alterations in breast cancer[J]. Metabolomics, 2016, 13 1. DOI: 10.1007/s11306-016-1138-y
[2] JUNG-MIN LEE  Dong S I  Soo Jin Park. Lysophosphatidylethanolamine increases intracellular Ca2+ through LPA1 in PC-12 neuronal cells[J]. Biochemical and biophysical research communications, 2015, 461 2: Pages 378-382. DOI: 10.1016/j.bbrc.2015.04.042