Basic information Safety Related Supplier

macbecin I

Basic information Safety Related Supplier
macbecin I Basic information
macbecin I Chemical Properties
  • Melting point:205-206 °C(Solv: ethanol (64-17-5); water (7732-18-5))
  • Boiling point:736.2±60.0 °C(Predicted)
  • Density 1.17±0.1 g/cm3(Predicted)
  • storage temp. Desiccate at -20°C
  • pka8.62±0.70(Predicted)
macbecin I Usage And Synthesis
  • Biological ActivityAnsamycin antibiotic compound that inhibits Hsp90 activity (IC 50 = 2 μ M) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC 50 ~ 0.4 μ M) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ).
macbecin I(73341-72-7)Related Product Information
macbecin ISupplierMore
  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
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  • Company Name:BOC Sciences
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